无并发性VRE细菌病的短期治疗:这是我们试图 (缩短治疗) 的方法
Eleazar Torres1, Nicole L Hlavacek1, M Gabriela Cabanilla1,2
1Department of Pharmacy, University of New Mexico Hospital, Albuquerque, NM, USA.
概括
与较长的疗程相比,短期 (≤6天) 治疗耐旺素抗Enterococcus (VRE) 细菌病的治疗没有增加复发,再入院或死亡的风险. 这表明,对精心挑选的患者来说,缩短治疗可能是安全的.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 药物治疗 药物治疗
背景情况:
- 对于抗万科胺素抗性肠球菌 (VRE) 细菌病的最佳治疗持续时间仍未确定.
- 较短的抗生素疗程可以减轻不良事件并减少住院时间 (LOS).
研究的目的:
- 为了比较短期 (≤6天) 与长期 (>6天) 抗生素治疗无并发性VRE细菌病的临床结果.
主要方法:
- 对48名没有并发性VRE细菌病的成年患者进行了回顾性单一中心研究 (2014-2024).
- 接受≤6天治疗的患者与接受>6天最终抗生素治疗的患者的比较.
- 主要结局:30天细菌病复发;次要结局:再入院,死亡率,LOS和不良事件.
主要成果:
- 在短期 (n=10) 或长期 (n=38) 组中没有观察到细菌病复发.
- 群体之间的30天和90天死亡率相似 (分别为30%vs21.1%和30%vs29%).
- 短期治疗与较短的中位数细菌病后医院LOS (10.5 vs 13天) 相关.
结论:
- 对无并发性VRE细菌病的短期治疗 (≤6天) 似乎是安全的,并且与复发,再入院或死亡率的增加无关.
- 这些发现产生了假设,并支持进一步研究为特定患者缩短治疗持续时间.
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