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Updated: Jan 8, 2026

Isolation of CD4+ T-cells and Analysis of Circulating T-follicular Helper cTfh Cell Subsets from Peripheral Blood Using 6-color Flow Cytometry
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系统性硬化症患者的改变的T细胞格局的特征是1型免疫功能失调

Victoria Volfson-Sedletsky, Hannah A DeBerg, Mitch L Fahning

    bioRxiv : the preprint server for biology
    |December 22, 2025
    PubMed
    概括

    系统性硬化症 (SSc) 患者表现出耗尽的T细胞,特别是表达CD8+和CD4-CD8-T细胞的T-bet缺乏,这对免疫至关重要. 这种缺陷会损害抗纤维性活性,导致慢性纤维化.

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