随着年龄的变化,DNA甲基化模式与整个寿命的血压有关
Gang Xu1, Xiaowei Zhuang1,2, Amei Amei3
1Laboratory of Neurogenetics and Precision Medicine, College of Sciences, University of Nevada Las Vegas, Las Vegas, NV. USA.
bioRxiv : the preprint server for biology
|December 22, 2025
概括
DNA甲基化模式随着年龄的增长而变化,并影响血压,揭示了动态的,与年龄相关的关联. 纵向研究揭示了与血管衰老和心血管风险相关的时间表观遗传变异.
科学领域:
- 遗传学和表观遗传学
- 心血管健康 心血管健康
- 衰老研究研究 衰老研究
背景情况:
- 全表观基因组关联研究 (EWAS) 将DNA甲基化与血压联系起来.
- 大多数研究使用单个时间点数据,缺少与年龄相关的动态.
- 了解年龄相关的表观遗传变化对于心血管健康至关重要.
研究的目的:
- 为了研究DNA甲基化和血压特征之间的年龄相关联系.
- 为了确定这些关系如何在一生中演变.
- 探索与年龄有关的心血管风险的潜在生物标志物.
主要方法:
- 纵向表观基因组范围的关联研究 (EWAS) 使用基于支线的变系数模型.
- 从多民族动脉样硬化研究 (MESA) 中分析了1945个血液样本.
- 在1,187个来自弗雷明汉心脏研究的样本中进行复制,对共变量进行调整.
主要成果:
- 六个CpG站点显示了显著的依赖年龄的关联与心压或脉压.
- 在独立队列中重复发现,包括STIP1,CSRP1和KDM6A.内的位置.
- 观察到甲基化-血压关联方向与年龄的逆转,涉及血管衰老路径.
结论:
- 血液DNA甲基化表现出与血压的动态,与年龄相关的关联.
- 这些发现反映了系统或血管衰老,而不仅仅是直接的细胞介导.
- 纵向的EWAS框架揭示了对于识别心血管风险生物标志物至关重要的时间表遗传模式.
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