白物质 BOLD 调解时间变化的皮层-皮层功能连接
Lyuan Xu1,2, Yurui Gao1,3, Muwei Li1,4
1Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN USA.
白质 (WM) BOLD信号显著调解大脑灰质 (GM) 关联,影响皮质区域如何相互作用. WM信号的时间变化,而不是振幅,跟踪动态GM-GM连接,揭示了WM.
科学领域:
- 神经成像是一种神经成像.
- 大脑的连接性 大脑的连接性
- 白物质的功能 白物质的功能
背景情况:
- 使用BOLD fMRI的功能连接 (FC) 研究通常集中在灰质 (GM) 信号上.
- 白质 (WM) 在神经网络组织和皮层-皮层通信中的作用经常被忽视.
研究的目的:
- 调查WM路径是否调解GM-GM功能关联.
- 探索动态WM BOLD信号与时间变化的内皮层FC之间的关系.
主要方法:
- 在休息状态的fMRI数据上使用了通道信息调解框架,来自人类连接体项目.
- 在灰色物质-白色物质-灰色物质 (GM-WM-GM) 单位的量化途径级调解效应.
- 分析了WM BOLD信号的时间动态与波动的GM-GM连接之间的关系.
主要成果:
- 发现WM BOLD信号显著调解了转基因-转基因关联,表现出路径依赖的异质性.
- WM信号的时间变化,而不是平均幅度,与动态GM-GM连接性相关 (r ≈ 0.4).
- 特定的WM路径显示出与皮层-皮层合有明显的关系.
结论:
- WM BOLD信号在大规模的大脑网络组织中起着不可或缺的作用.
- WM途径有助于皮层区域如何相互作用,挑战FC研究中对GM的专注.
- WM的动态特性对于理解时间变化的大脑网络功能至关重要.
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