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Updated: Jan 8, 2026

High-Resolution Mapping of Protein-DNA Interactions in Mouse Stem Cell-Derived Neurons using Chromatin Immunoprecipitation-Exonuclease ChIP-Exo
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在小鼠大脑中Chd8的分子相互作用突出显示了它在染色质关联RNA处理中的作用

Emily Smith1, Cesar P Canales1,2,3, Mathew W Kenaston4,5

  • 1UC Davis Center for Neuroscience, Davis, CA 95618, USA.

bioRxiv : the preprint server for biology
|December 22, 2025
PubMed
概括

染色体重塑剂CHD8,神经发育障碍 (NDD) 的风险基因,与RNA处理和细胞骨蛋白相互作用. 这揭示了在染色质关联RNA处理中对剂量敏感的作用,这对大脑发育至关重要.

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