大脑性别的个体间和个体内差异映射到神经内分泌特征
Gloria Matte Bon1,2, Ann-Christin S Kimmig1,2,3, Erika Comasco2
1Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany.
bioRxiv : the preprint server for biology
|December 22, 2025
概括
大脑的性别差异随着荷尔蒙水平的波动而波动,特别是在女性身上. 机器学习模型显示,口服避孕药的使用和月经周期阶段会影响大脑结构,显示与激素相关的可塑性.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 机器学习 机器学习
背景情况:
- 性激素显著影响大脑结构和功能.
- 了解性别类固醇水平与大脑性别差异之间的关系至关重要.
研究的目的:
- 为了研究性激素波动如何映射到大脑的性别差异.
- 探索与神经内分泌调节相关的大脑性别的个体间和个体内变异.
主要方法:
- 训练有素的机器学习模型用于大脑性别分类,使用来自1090个人的解剖数据.
- 将模型应用于各种荷尔蒙状态 (自然循环,口服避孕药使用,怀孕) 的个人密集采样数据.
主要成果:
- 与女性相比,在男性中观察到大脑性别的较低时间变化.
- 发现口服避孕药的使用与更像女性的大脑相关.
- 在月经周期阶段和妊娠三季度中确定 (反转) 的U形脑性轨迹.
结论:
- 大脑性别的变化反映了随着时间的推移与激素相关的可塑性.
- 神经内分泌调节显著影响大脑结构和性别差异化.
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