人类脏中等位基因特异性表达的景观
bioRxiv : the preprint server for biology
|December 22, 2025
概括
在球体而不是管中,基因特异性表达 (ASE) 表明蛋白尿性病中的保护性反应. 较高的淋巴细胞ASE与更好的患者结果相关,这表明适应性基因调节.
科学领域:
- 基因组学就是基因组学.
- 腎臟病學 (nephrology) 是一種醫學.
- 分子生物学分子生物学
背景情况:
- 对基因组调节至关重要,但其在病中的作用尚不清楚.
- 了解不同部位的ASE对于破译疾病机制至关重要.
研究的目的:
- 在人类病中创建ASE的全基因组地图.
- 调查ASE模式与病结果之间的关联.
主要方法:
- 配对的全基因组测序和RNA-seq从微切割的质细胞 (GLOM) 和管间隔膜 (TUBE) 区.
- 在蛋白尿性病患者中分析ASE事件.
主要成果:
- 在全基因组范围内确定了序列介导的确定性ASE事件.
- 在患病脏中,与管相比,在淋巴细胞中观察到显著更高的ASE.
- 发现增加的质ASE与改善的病结果相关.
结论:
- 淋巴细胞ASE作为蛋白尿性脏疾病中的适应性转录活性标志物.
- 升高的淋巴细胞ASE反映了一种保护性反应,包括对核糖体和ATP合成的上调.
- ASE模式在区之间有所不同,并且具有预后影响.
相关概念视频
External Anatomy of the Kidney
3.3K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
3.3K
Internal Anatomy of the Kidney
5.8K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
5.8K
Kidney Structure
74.6K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
74.6K
Renal Corpuscle
6.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
6.8K
Renal Tubule and Collecting Duct
3.0K
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
3.0K


