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Updated: Jan 8, 2026

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Author Spotlight: Development and Application of SERS Flexible Substrates Using Synthesized AgNPs

Published on: November 17, 2023

激光激活的微流体SERS基板

Milena S Shestopalova^1,2, Denis S Korzhov^1,2, Konstantin N Afanasyev³

¹Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia.

|December 22, 2025

概括

此摘要是机器生成的。

这项研究为微流体芯片引入了稳定,可激活的表面增强拉曼光谱 (SERS) 基板. 这些基质能够超灵敏地检测细胞外囊泡,这对于识别疾病生物标志物至关重要.

关键词:

凯尔文探针强力显微镜原子力显微镜的原子力显微镜.细胞外囊泡中的细胞外囊泡.实验室在芯片上的技术检测的检测极限.等离子体纳米结构的结构.表面增强的拉曼光谱学

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Fluorescence detection methods for microfluidic droplet platforms

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科学领域:

分析化学分析化学
生物技术是生物技术.
材料科学材料科学材料科学

背景情况:

自动化微流体系统与表面增强拉曼光谱学 (SERS) 结合,显示出超敏感生物材料检测的前景.
细胞外囊泡是疾病生物标志物 (microRNA,mRNA,蛋白质) 发现的关键目标.
现有的SERS基板,特别是基于银的基板,由于氧化和污染而遭受不稳定,限制了实际使用.

研究的目的:

开发一种新的制造方法和稳定,可激活的SERS基板的操作概念.
为了使SERS基质能够集成到自动化微流体系统中,以进行增强的疾病生物标志物分析.
为了克服当前SERS检测系统中时间不稳定的局限性.

主要方法:

在实验之前设计用于立即激活SERS基板的制造.
将非激活的SERS基质集成到微流体芯片中,以便长期存储而不会损失功能.
开发一个理论模型来评估局部电磁场增强.
实验性确定基质灵敏度用于细胞外囊泡检测.

主要成果:

展示了一种用于创建具有延长保质期和按需激活的SERS基板的方法.
验证了将这些基板集成到自动化系统的基于芯片的光谱记录室中的有效性.
实验结果证实了高灵敏度,使得可以从HEK293T细胞中快速检测单个细胞外囊泡及其.

结论:

拟议的SERS基板为微流体系统中超敏感的细胞外囊泡检测提供了稳定且实用的解决方案.
这一进步有助于开发用于疾病生物标志物分析的自动化平台.
这些发现为基于SERS技术的更可靠和更容易使用的诊断工具铺平了道路.