针对SARS-CoV-2感染和免疫激活的ACE2独立的进入因子
Yiyu Sun1,2, Lok-Yin Roy Wong3,4, Theresa L Chang2,3
1Rutgers School of Graduate Studies, Newark, New Jersey, USA.
mBio
|December 22, 2025
概括
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 可以独立于ACE2受体感染细胞. 这些替代途径对于了解疫苗接种或先前感染的个体的病毒传播和免疫反应至关重要.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 导致COVID-19,这是一个重大的全球健康问题.
- 病毒主要通过ACE2受体进入细胞,但其表达不能完全解释病毒分布或病理.
- SARS-CoV-2 可以感染缺乏 ACE2 的细胞,这表明涉及其他进入机制.
研究的目的:
- 审查ACE2独立进入因子在SARS-CoV-2感染中的新兴作用.
- 讨论这些因素如何影响免疫反应.
- 突出这些途径在接种疫苗或先前感染过的个体中的重要性.
主要方法:
- 对研究SARS-CoV-2进入机制的文献综述.
- 与ACE2表达相关的病毒热带和病理学的分析.
- 检查由ACE2独立感染引发的免疫反应.
主要成果:
- 确定了多个ACE2独立的进入因子,包括CD147,AXL和转激素受体1.
- 独立于ACE2的进入足以引起免疫反应.
- 这些途径可能会对针对ACE2-依赖性入口的抗体产生抗性.
结论:
- 在SARS-CoV-2感染动态中,ACE2独立的进入因素起着重要作用.
- 了解这些途径对于开发有效的治疗方法和疫苗至关重要,特别是针对变种.
- 需要进一步的研究来探索ACE2独立机制对病毒进化和免疫介导病理学的影响.
相关概念视频
Factors Affecting the Risk of Infection
13.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.2K
Antigens Involved in Adaptive Immunity
1.2K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
1.2K
Factors Affecting Illness
5.0K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
5.0K
Cross-reactivity
32.8K
Overview
32.8K
Autoimmune Disorders
1.4K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
1.4K
Immune Response Against Viral Pathogens
1.6K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.6K


