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Updated: Jun 20, 2026

Analysis of Group IV Viral SSHHPS Using In Vitro and In Silico Methods
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1-Hydroxy-1,8-napthyridinone (DHN) 类似物强烈抑制水病毒溶解酶 (Mpr)

Samuel Offei1, Jacob P Mahoney1, Ziyue Wang2

  • 1Center for Drug Design, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Journal of medicinal chemistry
|December 22, 2025
PubMed
概括

研究人员开发了新的mopox resolvase (Mpr) 抑制剂,对疫苗病毒 (VACV) 具有强大的抗病毒活性. 最好的化合物在Mpr抑制和VACV疗效方面显著改善,并具有有利的ADME特性.

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