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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
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用石榴提取物调节肠道微生物群:来自受控补充研究的见解

Sarah Lebrun1, Sébastien Crevecoeur2, Bernard Taminiau2

  • 1Laboratory of Food Technology, Department of Food Sciences, FARAH - Veterinary Public Health, University of Liège, B43b, Liège, 4000, Belgium.

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概括

石榴提取物补充剂改变了肠道微生物群的组成和代谢物产生. 该研究发现细菌多样性增加和特定细菌种群的变化,这表明对肠道健康的潜在益处.

关键词:
16S rRNA 是一个16S rRNA.细菌的代谢物是细菌的代谢物.埃拉吉塔尼尼尼 (Ellagitannin) 是一种有趣的植物.石榴提取物 石榴提取物在 SHIME® 产品中使用 SHIME®.乌罗立是一种酸盐.

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科学领域:

  • 微生物学 微生物学
  • 营养科学 营养科学
  • 胃肠病学 胃肠病学

背景情况:

  • 石榴的消费与健康益处有关,因为它含有多.
  • 多与结肠中的肠道微生物群相互作用,影响其组成和活性.

研究的目的:

  • 调查石榴提取物 (Oxylent®) 补充剂对肠道微生物群和代谢物产生的影响.
  • 为了评估1.3g/天和2.6g/天石榴提取物的剂量依赖作用.

主要方法:

  • 利用SHIME®系统模拟结肠条件.
  • 使用染色学和酶学检测评估的细菌代谢物 (SCFA,乳酸盐,尿酸氨酸).
  • 通过16S rRNA amplicon测序分析微生物组成.

主要成果:

  • 石榴提取物降低了L-和D-乳酸盐水平,高剂量进一步降低了D-乳酸盐.
  • 补充剂增加了总体的细菌多样性.
  • 观察到Prevotella和Enterocloster的丰度下降,以及Mitsuokella的剂量依赖性变化.

结论:

  • 石榴提取物影响肠道微生物群组成和代谢物概况.
  • 这些发现表明,石榴化合物可以有益地调节肠道微生物群.
  • 这些效应支持石榴在促进肠道健康方面的作用.