天然食类黄类apigenin通过调节AMPK/NF-κB/NLRP3信号轴缓解性结肠炎
Mengsha Zhou1,2, Xiaoshuang Mao1, Lin-En Zou3
1Beijing Life Science Academy, Beijing 102299, China.
作为一种天然化合物,apigenin通过减少炎症和氧化应激,有效地治疗小鼠的性结肠炎 (UC). 它针对关键路径,显示作为肠道健康的自然疗法有前途.
科学领域:
- 自然产品化学 自然产品化学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 性结肠炎 (UC) 具有高复发率和低缓解率的挑战,需要新的补充治疗.
- 素 (Api),一种在和菜中发现的黄类,具有已知的抗氧化和抗炎性质.
- 目前对UC的治疗策略通常需要更安全,更有效的选择.
研究的目的:
- 研究阿皮基宁 (Api) 作为性结肠炎 (UC) 补充治疗的治疗潜力.
- 在大肠炎的小鼠模型中阐明了阿皮根因抗炎作用的分子机制.
主要方法:
- 在小鼠中诱导急性结肠炎,使用2.5%的DSS.
- 给出了apigenin (Api),以评估其对疾病严重程度,氧化应激和炎症的影响.
- 研究了涉及AMPK,NF-κB和NLRP3炎症酶激活的分子机制.
主要成果:
- 阿皮基宁的使用显著缓解了DSS诱导的结肠炎症状,包括体重减轻,结肠缩短和疾病活动指数 (DAI) 分数.
- 阿皮治疗恢复了粘膜的完整性,并减少了结肠中氧化应激和炎症的标志物.
- 从机制上讲,发现阿皮基宁直接激活AMPK并与NLRP3结合,抑制NF-κB通路和NLRP3炎症酶激活.
结论:
- 原蛋白通过对AMPK/NF-κB/NLRP3轴的双重向,显示出对小鼠大肠炎的保护作用.
- 艾比协同抑制氧化应激和炎症,突出其作为肠道健康的天然抗炎剂的潜力.
- 这些发现支持apigenin作为性结肠炎的安全有效的补充治疗剂的潜力.
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