持续性功能障碍作为认知衰退和痴呆症的早期指标,在认知正常的老年人中是认知衰退和痴呆症的早期指标
Maryam Ghahremani1,2, Eric E Smith2,3,4, Zahinoor Ismail1,2,3,4,5,6
1Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Journal of Alzheimer's disease : JAD
|December 22, 2025
概括
在认知正常的老年人中,持续性功能障碍 (FI) 显著增加了认知衰退和痴呆的风险. 然而,过渡性FI与痴呆风险增加没有显著的关联.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 功能独立对于健康的衰老至关重要,也是痴呆症的关键指标,包括阿尔茨海默病.
- 功能障碍 (FI) 可能在痴呆症诊断之前,突出了早期风险识别的必要性.
- 描述FI模式可以改善对认知衰退和痴呆症发病率的预测.
研究的目的:
- 调查持续性功能障碍 (FI) 是否识别出发生认知衰退和痴呆症的高风险群体.
- 在认知正常的老年人中,区分与持续性与暂时性FI相关的风险.
主要方法:
- 来自国家阿尔茨海默氏症协调中心的11,793名认知正常的老年人的数据分析.
- 使用四个关键活动 (准备热饮料,用餐,购物,旅行) 计算功能障碍综合评分.
- 在认知衰退前超过三分之二的访问中存在的持久FI的操作化;使用Cox模型与暂时FI和没有FI组进行比较.
主要成果:
- 与没有FI相比,持久FI与认知衰退和痴呆症的发病率增加了2.12倍.
- 过渡性FI没有显示出与认知衰退和痴呆症风险增加的统计学意义上的关联 (HR=1.14).
- 这项研究包括164名持久FI患者,522名暂时FI患者,11107名没有FI患者.
结论:
- 基于其持续性的功能障碍 (FI) 风险的操作化是痴呆症预后的一个有希望的策略.
- 识别持续性FI可以帮助精确确定未来认知衰退和痴呆症风险较高的个体.
- 这种方法有助于完善痴呆症风险评估和潜在的早期干预措施.
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