人类乳头瘤病毒对精液参数和男性不孕症的影响:单中心研究
Stefan Matik1, Ana-Marija Bosilkovska1, Simona Bardakoska-Stefanovska1
1Private hospital for Obstetrics and Gynecology with IVF Center for Reproductive Medicine 'Plodnost', Bitola, North Macedonia.
JBRA assisted reproduction
|December 22, 2025
概括
精液人类乳头瘤病毒 (HPV) 与不孕男性的精液质量差有关. 这一发现表明,HPV可能导致男性不育,需要进一步研究其影响.
科学领域:
- 生殖医学 生殖医学
- 安德罗学与人类学
- 传染性疾病 传染性疾病
背景情况:
- 人类乳头瘤病毒 (HPV) 是一种常见的性传播感染.
- 精子HPV在男性不孕症中的作用仍然不完全理解.
- 评估精液HPV的存在及其与精液参数的相关性对于了解男性生殖健康至关重要.
研究的目的:
- 为了确定来自不育夫妇的男性的精液HPV的患病率.
- 调查精液HPV检测与各种精液质量参数之间的关联.
- 为了比较HPV阳性和HPV阴性不育男性和肥沃对照之间的精液质量.
主要方法:
- 一项涉及50名不育男性和10名不育对照者的病例控制研究.
- 精液样本使用计算机辅助精液分析 (CASA) 进行分析.
- 实时聚合酶链反应 (PCR) 用于HPV检测和基因定型.
主要成果:
- 在18%的不育男性和10%的肥沃对照中检测到HPVDNA.
- 在不育的男性中,HPV阳性与增加的渐进性移动性,多余残留细胞质的精子和减少的正常体相关.
- 与肥沃对照人群相比,HPV阳性不育男性的精子度,总运动精子数和精子形态减少显着较低.
结论:
- 精液HPV与不育男性的精子参数受损显著相关.
- 这些发现表明,HPV可能是导致男性不孕症的一个因素.
- 需要进一步的研究来阐明精液HPV在男性不孕症中的机制和临床影响.
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