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纳金宁对通过氧化和p38 MAPK炎症通路的cisplatin-testicular损伤的保护作用

Amirhesam Keshavarz Zarjani^1,2, Layasadat Khorsandi^1,2, Mohamad Heydari Kahkesh^1,2

¹Cellular and Molecular Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

JBRA assisted reproduction

|December 22, 2025

概括

纳灵宁 (NG) 通过降低小鼠的氧化应激,炎症和亡来预防西斯 (CIS) 诱导的男性不孕症. 这种黄类化合物显示出在化疗期间保持生育能力的治疗潜力.

科学领域:

生殖毒理学生殖毒理学
药理学药理学是指药理学的学科.
生物化学生化学

背景情况:

西斯普拉丁 (CIS) 化疗会通过氧化应激,炎症和亡引起丸损伤和不孕症.
关键的分子通路包括ROS,NF-κB和p38 MAPK,导致精子生成中断和的减少.
宁素 (NG) 是一种黄类化合物,具有抗氧化,抗炎和抗丧性质.

研究的目的:

在小鼠模型中研究纳灵宁 (NG) 对西斯 (CIS) 诱导的丸毒性的保护作用.
评估NG减轻丸中氧化应激,炎症和亡的能力.

主要方法:

雄性小鼠被分配到控制,CIS,NG或NG + CIS治疗组.
评估结果包括血清丸激素,氧化应激标志物 (TOS,TAC,OSI),炎症细胞因子 (TNF-α,IL-1β,IL-6),NF-κB激活,Bax/Bcl-2比率和p38 MAPK.
进行了丸组织的组织病理学和形态学分析.

主要成果:

NG治疗显著降低了CIS诱导的氧化应激标志物和促炎细胞因子.
NG抑制了NF-κB和p38的MAPK激活,并调节了Bax/Bcl-2比率,表明细胞亡减少.
组织学检查显示,在接受NG和CIS治疗的小鼠中,胚胎管结构和精子生成得到改善.

结论:

纳灵宁有效地抵消西斯普拉丁诱导的丸毒性.
通过减轻关键损伤途径,NG在化疗期间保持男性生育的治疗潜力.

关键词:

这就是MAPKK的意思.西斯普拉丁 (cisplatin) 是一种制剂.这是一种炎症炎症炎症炎症.在那里,有个叫做naringenin的东西.氧化应激是一种氧化应激.测试测试测试测试

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