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通过调节NS2B-NS3相互作用来抑制寨卡病毒蛋白酶

Andrew J Smith1, Muhammad Arslan Rahat1, Leonardo J Scaramozza1

  • 1Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, United States.

Biochemistry
|December 22, 2025
PubMed
概括

了解寨卡病毒蛋白酶动态是开发有效治疗的关键. 这项研究揭示了全抑制剂如何与蛋白酶结合,为针对寨卡病毒和相关黄病毒的新抗病毒疗法提供了洞察力.

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Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...