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在使用选择性色素再吸收抑制剂的患者中,肩部整体关节置换术后出现出血风险
Luca Katz1, Helen Zhang1, Manjot Singh2
1The Warren Alpert Medical School of Brown University, Providence, Rhode Island.
Rhode Island medical journal (2013)
|December 22, 2025
概括
选择性血红素再吸收抑制剂 (SSRI) 的使用不会增加在接受全肩关节整形手术 (TSA) 的患者的出血或血栓风险. 这些发现表明,目前的SSRI疗法可以在TSA的外科期间保持.
科学领域:
- 整形外科手术 整形外科手术
- 药理学 药理学是指药理学的学科.
- 患者安全 患者安全
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 通常用于治疗焦虑和抑郁症.
- 在接受全肩关节整形手术 (TSA) 的患者中,与SSRI使用相关的外科风险仍然不清楚.
- 了解这些风险对于优化患者护理和手术结果至关重要.
研究的目的:
- 评估SSRI使用与术后出血和输血风险之间的关联.
- 评估SSRI使用对其他术后并发症的影响,如深静脉血栓和肺栓塞.
- 为接受TSA的患者提供基于证据的指导来管理SSRI药物.
主要方法:
- 一项使用PearlDiver Mariner170数据库的回顾性队列研究.
- 纳入标准:18岁以上的焦虑/抑郁症患者接受初级TSA.
- 基于年龄,性别,查尔森并发症指数 (CCI) 和并发症的1:1病例控制匹配;SSRI用户和非用户之间的30天术后结果的比较.
主要成果:
- 该研究包括SSRI和对照组中的3,346名患者,其关键的人口和临床因素相匹配.
- 两组之间在术后出血,输血,深静脉血栓或肺栓塞率方面没有观察到统计学上显著的差异.
- 平均年龄为67.45±7.44岁,男性为72.03%,两组的平均CCI为1.04±1.07.
结论:
- 在接受TSA的焦虑或抑郁症患者中使用SSRI与术后出血或血栓事件的风险增加无关.
- 目前的SSRI疗法不需要仅仅基于TSA外科手术期间的出血或血栓问题而改变.
- 虽然风险不高,但建议在接受TSA的SSRI患者继续保持临床警.
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