瘤血管区域量化预测口腔状细胞癌的生存结果
Liyuan Yu1,2, Fuyan Li1,2, Jingfei Wang1,2
1Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.
Oral diseases
|December 22, 2025
概括
口腔状细胞癌 (OSCC) 侵袭性瘤前部的高血管区域与更好的患者存活率有关. 这一发现为OSCC患者提供了新的预后见解.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 医疗成像医学成像
背景情况:
- 口腔状细胞癌 (OSCC) 劫持瘤血管系统的生长.
- 在OSCC中血管分布的预后作用尚不清楚.
研究的目的:
- 在OSCC中调查血管面积 (VA) 的空间分布和预后意义.
- 开发和验证一种在不同瘤区域量化VA的方法.
主要方法:
- 一个开源管道用CD31染色全片图像量化了内瘤 (INT) 和侵入性瘤前部 (ITF) 区域的血管面积 (VA).
- 使用单变量和多变量方法分析了VA和患者存活率之间的关联.
- 研究结果在一个独立的队列中使用CD34染色验证.
主要成果:
- 与ITF相比,在INT中血管面积显著更高.
- 在ITF中增加的VA独立地预测了发现和验证队列中有利的整体生存率和无疾病生存率.
结论:
- 这项研究提供了第一个证据,将侵入性瘤前部的高血管区域与OSCC的更好的预后联系起来.
- 量化区域血管性可能为口腔癌患者提供有价值的预后信息.
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