在DIEP重建之前激素治疗的安全性:匹配的队列分析
Viren Patel1, Joseph Quick, Shannon Wu
1Department of Plastic Surgery, The Cleveland Clinic, Cleveland, OH.
Plastic and reconstructive surgery
|December 22, 2025
概括
激素治疗 (HT) 增加了自主乳房重建 (ABR) 后的并发症和静脉血栓栓塞 (VTE) 风险. 在ABR之前停止HT可能会改善患者的治疗结果并降低手术风险.
科学领域:
- 在瘤学瘤学.
- 整形外科 整形外科 整形外科
- 血管外科 血管外科
背景情况:
- 激素治疗 (HT) 对于受体阳性乳腺癌的治疗至关重要.
- 关于HT对自身乳房重建 (ABR) 结果的影响仍在争论中.
- 一些研究表明HT的并发症增加,而另一些研究表明术后安全性.
研究的目的:
- 调查手术前激素治疗 (HT) 对自主乳房重建 (ABR) 结果的影响.
- 为了比较患者接受ABR和没有HT的并发症率和flap结果.
- 为了确定HT是否会影响ABR后并发症的风险.
主要方法:
- 在2016-2020年期间接受ABR的85名患者的回顾性队列分析.
- 根据ABR并发症 (BMI,吸烟,辐射,糖尿病等) 的危险因素,患者与1:1匹配. ) 的情况.
- 队列被分为HT和非荷尔蒙治疗 (NH) 的队列.
主要成果:
- 接受HT治疗的患者的整体并发症率明显高 (28%对15%,p=0.04).
- 术后血栓形成和全损失的发生率在队列之间是相似的.
- HT显著增加了静脉血栓栓塞 (VTE) 的风险 (7.0%对0%,p=0.03).
结论:
- 手术前的激素治疗与ABR后的并发症增加和VTE风险增加有关.
- 这项匹配的队列研究提供了证据,表明在ABR之前停止HT.
- 进一步的研究可能会阐明HT停止的最佳时间,以减轻手术风险.
更多相关视频
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
619
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
15.0K
相关概念视频
01:12Hazard Ratio
548
The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial...
For example, in a clinical trial...
548
01:20Comparing the Survival Analysis of Two or More Groups
531
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
531