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在甲状腺眼病和女性生殖功能中的IGF-1R对抗性
Nicole M Sekula1, Leena Surapaneni2, Ahmet Ayaz1
1Department of Obstetrics, Gynecology and Reproductive Sciences, Division of Reproductive Endocrinology & Infertility, Yale School of Medicine, New Haven, CT, U.S.A.
Ophthalmic plastic and reconstructive surgery
|December 22, 2025
概括
作为一种类似胰岛素的生长因子-1受体 (IGF-1R) 抗剂的teprotumumab可以导致女性的月经异常. 本综述探讨了这些变化背后的机制,重点关注IGF-1RR.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胰岛素类生长因子-1受体 (IGF-1R) 在女性生殖健康中起着至关重要的作用.
- 作为IGF-1R抗剂的teprotumumab用于治疗甲状腺眼睛疾病.
- 在使用teprotumumab. teprotumumab的女性中,有事报告过月经异常.
研究的目的:
- 审查目前对IGF-1R在女性生殖中的作用的理解.
- 为了确定导致与teprotumumab治疗的妇女月经异常的机制.
- 探索IGF-1R对抗性和月经功能障碍之间的联系.
主要方法:
- 现有文献的叙述性审查.
- 确定报告teprotumumab月经变化的研究.
- 探索IGF-1R信号传递和生殖生理学文献,以形成一个假设.
主要成果:
- 月经异常,主要是异常,发生在5%-50%的患者治疗teprotumumab.
- IGF-1R在关键的生殖组织中表达:下丘脑,垂体,卵巢和子宫内膜.
- 这些发现表明teprotumumab诱导的月经变化的生物基础.
结论:
- IGF-1R对抗性可能会破坏卵巢卵泡发育,类固醇发育和排卵.
- 需要进一步的研究来阐明生殖干扰的确切机制.
- 长期影响和IGF-1R对抗的潜在持久损害需要研究.
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