葡萄糖类-1受体激活剂对超重或肥胖,非糖尿病患者骨折风险的影响
Evangelia Constantine1, Luke Enthoven, Riley Kahan
1From the University of Colorado School of Medicine, Aurora, CO (Constantine, Enthoven, Kahan and Lauder), the Department of Orthopedic Surgery, NYU Langone Health, New York, NY (Pflug), and the Denver Health Medical Center, Denver, CO (Lauder).
The Journal of the American Academy of Orthopaedic Surgeons
|December 22, 2025
概括
类似葡萄糖-1受体激动剂 (GLP-1RA) 可能会增加没有糖尿病的超重或肥胖患者的骨折风险. 这种风险在BMI为40或以上的人和68岁及以上的个人中更高.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 药理学 药理学是指药理学的学科.
背景情况:
- 类似葡萄糖-1受体激动剂 (GLP-1RA) 被广泛用于血糖控制和体重管理.
- GLP-1RA对非糖尿病患者骨健康的影响在很大程度上仍未被描述.
研究的目的:
- 调查GLP-1RA使用与超重和肥胖但没有糖尿病的患者骨折风险之间的关联.
- 确定在使用GLP-1RA时患骨折风险较高的特定患者亚组.
主要方法:
- 使用TriNetX数据库 (2015-2022) 的回顾性病例控制研究.
- 包括没有糖尿病的超重/肥胖患者,但不包括具有先前脆弱性骨折风险的患者.
- 倾向性得分匹配用于比较GLP-1RA用户和非用户之间的骨折风险.
主要成果:
- 使用GLP-1RA与骨折风险显著增加有关 (OR 1.19,CI [1.09至1.31]).
- 亚组分析显示,BMI≥40 (OR1.26,CI [1.04至1.52]) 和68岁及以上 (OR2.25至4.99) 的患者的骨折风险增加.
结论:
- 在非糖尿病,超重或肥胖个体中,GLP-1RA处方与骨折风险增加有关.
- 增加的风险在BMI≥40的患者和68岁以上的患者中尤其明显.
- 需要进一步的研究来为这些人群的GLP-1RA处方提供临床指南.
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