通过H NMR和HPSEC-MALLS/RI在联合疫苗制造中确保Hib囊多糖的结构完整性

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Wei Ma1, Yong Yu2, Nan Zhu2

  • 1Aimei Persist Biopharmaceutical Co Ltd, Zhejiang 315199, PR China; College of Pharmaceutical Sciences, Zhejiang University, Zhejiang 310058, PR China.

Vaccine
|December 22, 2025
PubMed
概括

在疫苗质量方面,Haemophilus influenzae b型 (Hib) 囊多糖体 (PRP) 的结构完整性至关重要. 新的分析方法证实,在Hib疫苗制造过程中,PRP结构得到保存.

关键词:
(1) H NMR 的时间.囊中的多糖化物.结合疫苗的结合疫苗这就是HPSEC-MALLS/RI.甲型b (Hib) 型流感血球菌 (Haemophilus influenzae) 的发生过程分析技术 (PAT) 是一种分析技术.质量控制 质量控制结构确认 结构确认

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