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Updated: Jan 8, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
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Published on: June 23, 2019

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新的pyrazolo[1,5-a]pyrimidine衍生物作为潜在的CDK2抑制剂和亡驱动的抗增殖剂

Ahmed Abd El-Hamed El-Rahmany1, Nadia A Khalil2, Mohamed S Nafie3

  • 1Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, 11562 Cairo, Egypt; Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt.

Bioorganic & medicinal chemistry
|December 22, 2025
PubMed
概括

新的pyrazolo[1,5-a]pyrimidine衍生物通过抑制CDK2.2,表现出强大的抗癌活性. 化合物21c是一种有前途的领先候选物,在低毒性结肠癌细胞中显示出显著的生长抑制和亡诱导.

关键词:
它具有抗癌活性.在CDK2中使用CDK2.库马林是一种素.激酶抑制剂的使用这是一种Pyrazolopyrimidine.这种药物是三醇.

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