巴西多发性硬化症患者的流行病学和医疗保健准入:BRANDO数据库的见解
Alfredo Damasceno1, Cintia Ramari2, Carlos Tauil3
1Universidade Estadual de Campinas, Faculdade de Ciências Médicas, Departamento de Neurologia, Campinas SP, Brazil.
Arquivos de neuro-psiquiatria
|December 22, 2025
概括
这项研究揭示了巴西多发性硬化症 (MS) 流行病学和医疗保健获取方面的区域差异. 定制的管理策略对于解决MS护理中的这些差异至关重要.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 多发性硬化症 (MS) 是一种炎症性和神经退行性疾病,在巴西的患病率各不相同.
- 缺乏全面的国家流行病学研究,阻碍了巴西多元人口对多发性硬化症的充分理解.
研究的目的:
- 为了比较巴西四个不同地区的流行病学数据和MS患者的医疗保健准入情况.
- 确定多发性硬化患者人口统计,临床结果和治疗准入方面的区域差异.
主要方法:
- 在多发性硬化症协作拉丁美洲数据库 (BRANDO) 中,分析了来自巴西2,974名多发性硬化症患者的数据.
- 评估人口特征,临床结果 (包括扩展残疾状况表 (EDSS)) 和医疗保健准入指标.
- 统计分析以阐明MS流行病学和患者护理的区域差异.
主要成果:
- 该队列主要是女性 (72.5%),平均发病年龄为30.6岁.
- 在种族,残疾分数 (EDSS),MS亚型 (RRMS,PPMS,SPMS) 和诊断和治疗的时间方面观察到显著的区域差异.
- 东北地区的诊断延迟时间较长 (5.9年),MS进展率较高,而中西部地区更快地获得疾病修饰疗法 (DMT).
结论:
- 这是巴西首次对MS进行全国范围的流行病学研究,突出显著的区域差异.
- 有证据表明,多发性硬化症流行病学和获得医疗保健方面的差异很大,因此需要针对多发性硬化症管理和研究采取特定区域的方法.
- 调查结果要求进行量身定制的干预措施,以改善巴西MS患者的诊断,治疗和整体护理.
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