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早期发生的全胆固醇异常与灰色质缩和微观结构完整性下降有关

Ling Yang¹, Ying Hui², Mingze Xu³

¹Department of Radiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yongan Road, Xicheng District, Beijing, 100050, China.

Journal of lipid research

|December 22, 2025

概括

在45岁之前早期的总胆固醇 (TC) 异常与大脑结构损伤有关,包括减少灰质体积和白质完整性. 早期控制TC对于保持大脑健康至关重要.

科学领域:

神经学神经学
心血管健康心血管健康
神经成像是一种神经成像.

背景情况:

异常的总胆固醇 (TC) 可以导致渐进的脑损伤.
早期出现的TC异常意味着健康风险的累积.
早期TC异常对大脑结构的影响尚不清楚.

研究的目的:

研究早期TC异常对大脑宏观结构和微观结构的影响.
为了比较正常TC,早期TC异常和晚期TC异常的个体的大脑形态.

主要方法:

利用了来自凯卢安研究的16年随访数据.
将参与者分为正常的TC,早期发病 (<45岁) 和晚期发病 (≥45岁) 的TC异常组.
采用多式神经成像和通用线性模型来评估大脑体积,白质完整性和与TC水平的关联.

主要成果:

早期出现的TC异常与灰质体积 (额叶,海马) 减少以及白质完整性 () 降低相关.
晚期开始的TC异常显示了额叶体积的减少和弧形带损伤.
认知分数 (MoCA) 与灰质体积和白质完整性有关,特别是在早期发病组.

结论:

早期出现的TC异常与灰质缩和微观结构完整性受损有关.
这些发现强调了早期TC管理对于预防大脑形态损伤的重要性.
在生命早期积极的TC控制对于维持长期大脑健康至关重要.

关键词:

大脑形态学大脑形态学这是早期发病的.灰色物质是一种灰色物质.总胆固醇总的胆固醇.白质是白色物质的组成部分.

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