婴儿肠道微生物组和精神病风险的代际传播
Ellen Jopling1, Avril Metcalfe-Roach2, Stuart E Turvey3
1Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Laboratories of Cognitive Neuroscience, Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.
Brain, behavior, and immunity
|December 22, 2025
概括
母亲产前压力通过生命早期的微生物群影响孩子的心理健康. 早期的微生物组发育调解了母亲的压力和后代内化症状之间的联系,涉及免疫系统的途径.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 发展心理学 发展心理学
背景情况:
- 产前压力与儿童精神病风险增加有关.
- 代际风险传播的机制尚未完全理解.
- 生命早期的微生物组是对后代心理健康产生的母亲压力影响的潜在调解者.
研究的目的:
- 调查母亲产前压力,早期生命微生物组和儿童内化症状之间的机制关联.
- 阐明生命第一年微生物组的动态变化如何调解产前压力对儿童心理健康的影响.
主要方法:
- 利用了加拿大最大的深度表型出生队列 (n=2,985).
- 采用全信息最大概率分析方法.
- 检查了母亲感知到的压力,微生物群多样化和孩子在5岁时内化症状之间的联系.
主要成果:
- 早期的微生物群多样化显著调解了母亲产前压力和后代内化症状之间的关系.
- 受到早期多样化的影响的特定微生物种类与免疫系统途径有关.
- 这些发现表明,微生物组的成熟动态在生物学上嵌入了产前压力效应.
结论:
- 生命早期的微生物群,特别是其多样化,充当传递产前压力影响到后代心理健康的机制.
- 在这种途径中涉及的微生物变化涉及免疫系统调节.
- 这项研究将微生物组科学,发育心理学和精神病风险研究联系在一起,为未来的多学科研究铺平了道路.
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