探索一种双模仿性粘液惰性纳米复合物,用于增强口服胰岛素的输送
Qiyao Zhai1, Shuang Guo1, Zhixiang Cui1
1School of Pharmacy, Shenyang Key Laboratory of Intelligent Mucosal Drug Delivery Systems, Shenyang Pharmaceutical University, Shenyang 110016, China.
概括
新的口服胰岛素输送系统使用双模仿纳米复合体. 这些系统增强了粘液的透和肠道吸收,为有效的口服胰岛素输送提供了一个有前途的平台.
科学领域:
- 生物材料科学 生物材料科学
- 药物运输 药物运输 药物运输 药物运输
- 纳米技术纳米技术
背景情况:
- 口服胰岛素的输送面临着粘液透和肠道吸收的挑战.
- 聚电解质纳米复合物 (PEC) 提供无溶剂合成,但需要提高效率.
- 氨酸的特性激发了提高跨越生物障碍的药物输送策略的策略.
研究的目的:
- 开发使用粘膜透纳米复合物的增强口服胰岛素输送系统.
- 为了提高胰岛素装载PEC的粘液透性和跨上皮传输.
- 创建一个双模仿平台,以粘素和病毒为灵感,用于口服药物输送.
主要方法:
- 合成的氨酸,氨酸和氨酸 (PTS) 修改了氨酸 (CS) 以模仿粘素.
- 使用修改后的CS,胰岛素和氨酸 (HA) 涂层制造的粘液透纳米复合体.
- 评估了物理稳定性,酶降解,粘液透,以及体内低血糖效应.
主要成果:
- (PTS-CS/Ins) /HA纳米复合体表现出良好的物理稳定性和加强对酶降解的保护.
- 与未经修改的PEC相比,观察到通过粘液和小肠的透效率增加.
- 在体内研究显示,胰岛素相对药理可用性增加了2.16倍.
结论:
- 双模仿粘膜透纳米复合体 (PTS-CS/Ins/HA) 显示出可口胰岛素输送的显著潜力.
- 该策略有效地提高了粘液的透性和胰岛素的肠道吸收.
- 这种病毒和菌体启发的平台为口服药物输送系统提供了有前途的进步.
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