在手术,脏和神经学队列中,EBV和CMVDNAemia
Adnan A Mubaraki1, Abdullah S Alqahtani2, Anas A Alshamrani2
1Department of Medicine, College of Medicine, Taif University, Taif 21944, Saudi Arabia.
Acta tropica
|December 22, 2025
概括
埃普斯坦-巴尔病毒 (EBV) 和细胞巨乳病毒 (CMV) DNAemia 总体来说很少发生,但在儿科,外科和科患者中很常见. 在神经系统疾病中发现了有限的EBV/CMV参与.
科学领域:
- 病毒学 病毒学
- 传染性疾病 传染性疾病
- 分子诊断学 分子诊断
背景情况:
- 爱普斯坦-巴尔病毒 (EBV) 和细胞巨化病毒 (CMV) 是常见的疹病毒,与各种疾病有关.
- 评估EBV和CMVDNAemia的患病率对于了解它们在不同疾病中的影响至关重要.
研究的目的:
- 为了确定爱斯坦-巴尔病毒 (EBV) 和细胞巨乳病毒 (CMV) 的流行率DNAemia.
- 调查EBV和CMVDNAemia与人口和临床因素的关联.
- 在患有神经系统疾病的患者中评估EBV和CMVDNAemia的存在.
主要方法:
- 回顾性和前性队列研究设计.
- 在2463名患者中用于EBV和CMVDNA检测的定量PCR (qPCR).
- 对与病毒DNAemia相关联的人口统计和临床数据的分析.
主要成果:
- 在15.3%的患者中检测到EBVDNAemia,与年龄和临床类别显著相关 (在外科和儿科组中最高).
- 在11.4%的患者中检测到CMVDNAemia,其中"其他"和科组的数字最高;低水平的DNAemia占主导地位.
- 在神经学队列中,EBV或CMVDNAemia在5.9%的病例中被检测到,所有病例都是低水平的,没有显著的关联.
结论:
- EBV和CMV感染不常见,但在儿科,外科和脏病患者亚组中显示有选择性的分布.
- 有限的证据表明,EBV/CMV与特定的神经系统疾病有关.
- 定量PCR在不同患者群体中有效检测EBV和CMVDNAemia.
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