一个无线,60频道,AI启用的神经刺激平台
Daniel S Rizzuto1, Haydn G Herrema1, Zhe Hu1
1Nia Therapeutics, Inc., Allston, 02134, MA, USA.
Brain stimulation
|December 22, 2025
概括
智能神经刺激系统 (SNS) 解码大脑状态,并使闭环神经调节成为可能. 这种临床前设备对准与记忆和认知有关的大脑网络显示出希望.
科学领域:
- 神经科学是一个神经科学.
- 生物医学工程 生物医学工程
- 神经调节是一种神经调节.
背景情况:
- 闭环神经调节疗法需要先进的设备,能够实时解码大脑状态和多站点刺激.
- 当前的技术往往缺乏在自由移动的对象中无操作所需的集成.
研究的目的:
- 引入和评估智能神经刺激系统 (SNS),这是一种用于闭环神经调节的新型植入装置.
- 为了证明该设备在高密度神经记录,大脑状态解码和体内可编程刺激方面的能力.
主要方法:
- 智能神经刺激系统 (SNS) 是安装在头骨上的植入物,具有60个可配置的记录/刺激通道,感应功率和车载光谱特征分类.
- 在三个自由移动的绵羊身上进行了实验,涉及本地场潜在的流动和参数扫描刺激协议.
主要成果:
- 运动分类器通过交叉验证实现了高精度 (平均AUC>0.95).
- 具有不同幅度和频率的刺激导致目标皮质区域的α和gamma频带功率可观测增加.
结论:
- SNS成功地将高密度传感,实时大脑状态解码和闭环刺激集成到一个可植入的装置中.
- 这项研究表明,生物标志物引导刺激的潜力针对分布式皮质网络,这对记忆和认知至关重要.
更多相关视频
09:52Measuring and Manipulating Functionally Specific Neural Pathways in the Human Motor System with Transcranial Magnetic Stimulation
Published on: February 23, 2020
9.7K
05:19Author Spotlight: Therapeutic Benefit of Closed-Loop Deep Brain Stimulation in Depression Treatment
Published on: July 7, 2023
3.2K
相关概念视频
01:20Motor Unit Stimulation
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
01:22Muscle Stimulation Frequency
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...