血清FGF21和GDF15水平及其与双相情感障碍中认知功能的关联
Yağmur Darben Azarsız1, Aybeniz Civan Kahve2, Ezgi Sıla Ahi Üstün3
1Department of Psychiatry, University of Health Sciences, 06800, Ankara Bilkent City Hospital, Ankara, Türkiye.
纤维细胞生长因子21 (FGF21) 和生长差异化因子15 (GDF15) 的升高与双相情感障碍 (BD) 的认知缺陷有关. FGF21与执行功能有着显著的关联,这表明它在BD神经生物学中的作用.
科学领域:
- 神经科学是一个神经科学.
- 生物标志物 生物标志物
- 精神疾病 精神疾病
背景情况:
- 纤维细胞生长因子21 (FGF21) 和生长分化因子15 (GDF15) 是线粒体压力生物标志物,与精神疾病有关.
- 它们在双相情感障碍 (BD) 中认知功能障碍中的作用尚不清楚.
研究的目的:
- 为了比较血清FGF21和GDF15水平在euthymicBD患者与健康对照.
- 检查这些生物标志物与BD患者认知表现之间的关系.
主要方法:
- 174名参与者 (87名BD,87名对照) 进行了认知测试 (WCST,Stroop,TMT).
- 血清FGF21和GDF15水平使用ELISA量化.
- 通过相关性和多重回归分析的数据.
主要成果:
- 在BD患者中,FGF21和GDF15水平显著上升.
- BD患者在执行功能,注意力和处理速度方面表现较差.
- FGF21与更好的认知表现相关 (TMT时间更短,Stroop干扰更少);GDF15与临床因素相关,但与认知没有直接关系.
结论:
- FGF21和GDF15可能表明线粒体功能障碍和BD中的疾病负担.
- 在BD中,FGF21与执行功能和认知灵活性特别相关.
- 在双相情感障碍中,FGF21可能在认知障碍的神经生物学机制中发挥作用.
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