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Updated: Jan 8, 2026

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在tRNA修饰突变体中,低于最佳的编码对触发了核糖体碰撞和细胞质量控制反应

Jie Wu1,2, Cristian Eggers1,2, Olga Sin1

  • 1Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP), University of Bern, Bern 3012, Switzerland.

Nucleic acids research
|December 22, 2025
PubMed
概括

转移RNA (tRNA) 的修改调节了蛋白质合成. 波动尿素 (U34) 修饰的损失导致核糖体停滞,触发质量控制途径以维持蛋白质平衡.

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