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Updated: Jan 8, 2026

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
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Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

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对CYP450融合蛋白 (CYPLY) 的基质耐受机制和域协同工程的动态分析

Yisang Zhang1,2, Yuanwei Wang1,2, Huiying Zhu1,2

  • 1State Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology, Jinan 250353, China.

Journal of agricultural and food chemistry
|December 22, 2025
PubMed
概括

工业用途的细胞染色体P450 (CYP450) 酶工程通过了解基质抑制和电子转移而得到了推进. 这项研究揭示了一种协同模型,将关门动态与提高酶性能联系起来,并确定了用于增强催化力的关键突变.

关键词:
在CYP450的基础上.动态分析 动态分析电子转移是电子的转移.抑制基质的抑制.

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