相关实验视频
Updated: Jan 8, 2026

Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
[带有PTEN突变的甲状腺瘤的临床病理和遗传特征]
1Department of Pathology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
带有PTEN突变的甲状腺瘤往往缺乏特征性PTEN哈马托马综合征的特征,并且表现出不同的PTEN表达. 与BRAF,TERT和TP53的共同突变很常见,这表明这些甲状腺瘤中存在复杂的遗传变异.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 病理学 病理学 病理学
背景情况:
- PTEN突变与各种癌症有关,但它们在甲状腺瘤中的作用需要进一步阐明.
- PTEN Hamartoma综合征 (PHTS) 评分系统 (THiPS) 是为了评估特征性形态特征而开发的.
- 了解PTEN突变甲状腺瘤的临床病理和遗传情景对于诊断和治疗至关重要.
研究的目的:
- 分析带有PTEN突变的甲状腺瘤的临床病理特征.
- 评估THiPS评分系统在这些瘤中的诊断实用性.
- 为了确定与甲状腺瘤中PTEN变异相关的常见共变异.
主要方法:
- 对10例带有PTEN突变的甲状腺瘤病例的回顾性分析.
- 使用THiPS评分系统量化组织形态特征.
- 免疫组织化学染色用于PTEN表达和下一代测序用于遗传分析.
主要成果:
- 带有PTEN突变的甲状腺瘤表现出较低的THiPS得分,缺乏特征性的PHTS形态.
- PTEN表达有所变化,在7例病例中出现损失,在3例无意识突变病例中呈阳性染色.
- 共同突变很常见 (80%),包括BRAF,TERT促进体和TP53,其中有2例仅显示PTEN突变.
结论:
- 对于带有PTEN变化的甲状腺瘤,THiPS得分具有有限的诊断价值.
- 阴性PTEN免疫组织化学可能表明突变,但阳性染色不排除它.
- 在甲状腺瘤中,PTEN突变经常与BRAF,TERT和TP53变异同时发生.
更多相关视频
06:08Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
Published on: June 2, 2023
09:33Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
Published on: August 25, 2023
相关概念视频
Abnormal Proliferation
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Loss of Tumor Suppressor Gene Functions
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...