循环炎症蛋白与精神分裂症,双相情感障碍和严重抑郁症风险相关:一项门德尔随机化研究
Zhe Dong1, Bin Bi2, Ruoming Li1
1Peking University HuiLongGuan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China.
Translational psychiatry
|December 22, 2025
概括
这项研究使用了门德尔的随机化来研究95种炎症蛋白和精神疾病之间的联系. 某些蛋白质,如C-反应蛋白 (CRP),可能会防止精神分裂症 (SCZ),而其他蛋白质则会增加风险.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
- 免疫学 免疫学 免疫学
背景情况:
- 精神分裂症 (SCZ),双相情感障碍 (BD) 和严重抑郁症 (MDD) 分享遗传和环境风险因素,免疫-炎症失调与它们的病理生理学有关.
- 炎症蛋白和这些疾病之间的因果关系需要进一步澄清.
研究的目的:
- 通过孟德尔随机化 (MR) 评估95种循环炎症蛋白与SCZ,BD和MDD风险之间的关联.
- 为了澄清因果关系的方向,调查重叠效应,并确定蛋白质和疾病之间的共同遗传变异.
主要方法:
- 一个两样本的门德尔随机化 (MR) 研究,利用大规模的全基因组关联研究 (GWAS) 总结统计数据.
- 采用了双向MR,多变量MR,局部化分析,敏感性分析和元分析.
- 使用了来自精神病基因组学联盟 (PGC) 的发现数据和来自FinnGen生物库的验证数据.
主要成果:
- 较高的C-反应蛋白 (CRP) 和分蛋白 (CX3CL1) 与SCZ风险降低有关;与Delta和Notch类表皮生长因子相关的受体 (DNER) 和真核细胞翻译启动因子4E结合蛋白1 (EIF4EBP1) 与SCZ风险增加有关.
- 纤维细胞生长因子23 (FGF23) 和介质蛋白-20 (IL20) 与减少MDD风险有关;瘤缩因子连接物超级家族成员12 (TNFSF12) 与增加MDD风险有关.
- 在C-X-C基因化基因5 (CXCL5),TRANCE和CC基因化基因连接体7 (CCL7) 显示与BD有保护性关联. 发现了强有力的证据,表明DNER和SCZ之间有共同的遗传变异.
结论:
- 这项MR研究表明,特定的循环炎症蛋白与精神疾病之间存在潜在的因果关系.
- 这些发现突出了SCZ中CRP和CX3CL1,MDD中FGF23和IL20的潜在保护作用,而DNER,EIF4EBP1和TNFSF12可能会增加风险.
- 鉴定到的共同遗传变异,特别是DNER和SCZ之间的共同遗传变异,为神经精神病学病原体和潜在的治疗点提供了洞察力.
相关概念视频
Biological Causes of Schizophrenia
458
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
458
Psychological and Sociocultural Causes of Schizophrenia
438
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
438
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
1.8K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
1.8K
Bipolar Disorder
586
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
586
Human Genetics
1.4K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
1.4K
Mania and Antimanic Drugs: Overview
526
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
526


