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Updated: Jan 8, 2026

Testing Targeted Therapies in Cancer using Structural DNA Alteration Analysis and Patient-Derived Xenografts
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mTORC2抑制通过STAT1激活和对抗PD-L1治疗的增强反应来降低瘤负担

Anna Gschwendtner1, Birgit Schütz1, Madalina A Mirea1

  • 1Institute of Medical Genetics, Center for Pathobiochemistry and Genetics, Medical University of Vienna, Vienna, Austria.

Cell death & disease
|December 22, 2025
PubMed
概括

在黑色素瘤中准Rictor-AKT通路通过增强干扰素信号传递和减少PD-L1和IGF-1等免疫抑制因子来提高抗瘤免疫力. 这种方法可以改善对免疫治疗的反应.

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