在同时接种COVID-19和流感疫苗后,缓解免疫印记的探索性证据
Min Joo Choi1, WonSeok Gwak2, Jae Young Yun3
1Division of Infectious Diseases, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea.
NPJ vaccines
|December 22, 2025
概括
同时接种COVID-19和流感疫苗是可行的,没有显示免疫干扰. 联合注射可能会提供增强的变异特异性免疫反应,这表明未来对疫苗策略的研究可能会有潜在的益处.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 同时接种COVID-19和流感疫苗是常见的,但对变种特异性免疫反应的长期数据有限.
- 了解潜在的免疫干扰和长期免疫原性对于优化疫苗接种计划至关重要.
研究的目的:
- 为了评估与单独管理相比,同时使用双价值COVID-19 mRNA助推剂和四价值流感疫苗的长期免疫性和潜在免疫干扰.
- 评估变体特异性抗体反应,特别是针对Omicron BA.5.5的抗体反应.
主要方法:
- 一项为期10个月的前性研究,涉及80名参与者,分为同时接种疫苗 (C组) 和单独接种疫苗 (S组).
- 通过抗S IgG,抗受体结合域 (RBD) IgG,焦点减小中和试验 (FRNT) 和血液凝结抑制试验评估免疫性.
- 对野生型 (WT) 和Omicron BA.5菌株进行测量的抗体反应.
主要成果:
- 两组人都表现出强大的免疫反应长达10个月,没有显著的免疫干扰.
- 10个月后,对WT和Omicron BA.5的抗体反应在两组之间是可比的.
- 同时接种疫苗 (C组) 显示1个月后对Omicron BA.5的中和抗体标位较高,并且在FRNT中增强了中和效率和BA.5-to-WT比率,这表明免疫印记的潜在缓解.
结论:
- 同时接种流感和COVID-19疫苗是可行的和安全的,没有免疫干扰的证据.
- 随着同时服用观察到的增强的变异特异性免疫反应需要进一步调查.
- 研究结果支持联合疫苗接种策略,并表明对变种保护的潜在免疫学优势.
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