尿道菌毒素生物标志物的同时发生模式和中国三个典型地区的人口累积风险评估的比较研究
Ying-Ying Zhou1,2, Ming-Lu Li1,3, Xiao-Dan Wang1
1China National Center for Food Safety Risk Assessment, Beijing, China.
Journal of exposure science & environmental epidemiology
|December 22, 2025
概括
在中国人群中发现了高水平的脱氧尼瓦伦醇 (DON) 和同时出现的真菌毒素,这对健康构成重大风险. 这项生物监测研究强调了需要策略来减轻菌根毒素暴露及其有害影响.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 生物监测研究调查不同中国人群的尿液中的多菌毒素生物标志物.
- 专注于三个不同的地理位置,不同的饮食模式.
研究的目的:
- 为了全面了解中国人口对多种真菌毒素的内部暴露特征.
- 在不同的环境和饮食条件下,评估与毒素暴露相关的健康风险.
主要方法:
- 在使用UHPLC-MS/MS的311名健康志愿者的尿样中分析了7种真菌毒素生物标志物 (DONt,β-ZEL,NIV,α-ZEL,DAS,ZEN,AFM1).
- 根据尿液生物标志物度估计可能的每日摄入量 (PDI),危险系数 (HQ) 和危险指数 (HI).
主要成果:
- 脱氧尼瓦伦醇 (DON) 是最常见的真菌毒素 (100%),显著比例超过健康风险值 (HQ>1为61.09%).
- 在64.31%的样本中观察到两种或多种真菌毒素的同时存在,其中DONt-ZENt和DONt-ZENt-NIV组合是最常见的.
- 对于DONt-ZENt (61.09%) 和DONt-ZENt-NIV (69.77%) 的高危险指数 (HI) 值表明大量的累积健康风险.
结论:
- 这项研究提供了对中国多种真菌毒素共发生模式和累积风险的首次全面分析.
- 这些发现揭示了饮食,环境因素和真菌毒素暴露之间的关键联系,为健康风险评估提供了信息.
- 提供科学证据支持减轻真菌毒素对脆弱人群的不良健康影响的战略.
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