在使用皮肤导向的少侵入性表面活性剂管理期间疼痛评估:前性队列研究
Coralie Dirler1, Vinzenz Boos1, Dirk Bassler1
1Newborn Research, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Pediatric research
|December 22, 2025
概括
皮肤导电性 (SC) 在较少侵入性表面活性剂 (LISA) 管理期间没有显示早产婴儿的疼痛反应增加. 研究结果表明,SC可能不是新生儿的可靠疼痛指标,强调需要更好的客观疼痛评估方法.
科学领域:
- 新生儿护理 新生儿护理
- 疼痛评估 疼痛评估 疼痛评估
- 生理监测是指对身体进行生理监测.
背景情况:
- 较少侵入性表面活性剂管理 (LISA) 是表面活性剂缺乏的标准.
- 对于LISA的模拟坐标协议需要进一步调查.
- 对早产婴儿的客观疼痛评估仍然是一个挑战.
研究的目的:
- 评估皮肤导电性 (SC) 作为一个客观的疼痛度量在LISA期间在早产婴儿.
- 将SC测量与新生儿疼痛,兴奋和镇静量表 (N-PASS) 的分数进行比较.
- 评估SC在新生儿过程性疼痛检测中的可靠性.
主要方法:
- 对早产婴儿 (怀孕27周以上) 的前性队列研究.
- 通过皮肤导电性 (SC) 和盲目的新生儿疼痛,兴奋和镇静量表 (N-PASS) 评分来评估疼痛.
- 主要结果:在关键程序事件期间,每秒 (PPS) SC峰值的变化.
主要成果:
- 在大多数LISA事件中,SC-PPS没有显著增加,除了鼻管插入外,在年龄调整后没有显著增加.
- N-PASS评分显示了鼻管插入和喉镜检查期间的疼痛.
- 在SC和N-PASS得分之间观察到较弱的相关性 (肯达尔的 τB = 0.17).
结论:
- 皮肤导电性监测没有反映LISA期间疼痛增加,尽管N-PASS得分更高.
- 在早产婴儿出生后立即进行疼痛评估时,SC可能存在技术限制.
- 需要进一步的研究来验证对新生儿的客观疼痛评估工具.
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