Jove
Visualize
联系我们

相关概念视频

Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Evaluating generalization in protein-ligand cofolding methods.

Nature structural & molecular biology·2026
Same author

Single-amino acid variants in target epitopes can confer resistance to antibody-based therapies.

Science translational medicine·2025
Same author

Progress and Bottlenecks for Deep Learning in Computational Structure Biology: CASP Round XVI.

Proteins·2025
Same author

Protein Target Highlights in CASP16: Insights From the Structure Providers.

Proteins·2025
Same author

Assessment of Pharmaceutical Protein-Ligand Pose and Affinity Predictions in CASP16.

Proteins·2025
Same author

The Viral AlphaFold Database of monomers and homodimers reveals conserved protein folds in viruses of bacteria, archaea, and eukaryotes.

Science advances·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: May 8, 2026

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry
08:04

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry

Published on: March 13, 2014

12.6K

一个完全自动化的基准测试套件,用于比较宏分子复合体.

Gabriel Studer1,2, Xavier Robin1,2, Stefan Bienert1,2

  • 1Biozentrum, University of Basel, Basel, Switzerland.

Nature methods
|December 22, 2025
PubMed
概括

本研究回顾了蛋白质结构预测得分方法,这对于评估基于AI的模型至关重要. 提出了新的可扩展方法来评估复杂的蛋白质结构和相互作用.

更多相关视频

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

Published on: January 24, 2018

16.9K
Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
10:01

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

20.3K

相关实验视频

Last Updated: May 8, 2026

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry
08:04

A New Approach for the Comparative Analysis of Multiprotein Complexes Based on 15N Metabolic Labeling and Quantitative Mass Spectrometry

Published on: March 13, 2014

12.6K
Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology
11:20

Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology

Published on: January 24, 2018

16.9K
Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies
10:01

Combining Chemical Cross-linking and Mass Spectrometry of Intact Protein Complexes to Study the Architecture of Multi-subunit Protein Assemblies

Published on: November 28, 2017

20.3K

科学领域:

  • 计算生物学是一种计算生物学.
  • 结构生物信息学 结构生物信息学
  • 科学中的人工智能.

背景情况:

  • 蛋白质结构预测具有长期的基准测试努力的历史.
  • 人工智能的兴起需要对大型数据集进行强大的,不受监督的评分.
  • 实验结构的日益复杂性挑战了当前的比较方法.

研究的目的:

  • 审查当前在蛋白质结构预测中的评分方法.
  • 为了确定现有的评分方法的局限性.
  • 提出改善的方法来评分三级,四级和复杂相互作用.

主要方法:

  • 审查最先进的评分方法.
  • 为大型和复杂的系统开发可扩展的评分方法.
  • 在OpenStructure基准测试框架内实施.

主要成果:

  • 确定当前蛋白质结构评分的局限性.
  • 介绍各种结构特征的新,高效的评分方法.
  • 在开源的OpenStructure软件中开发的方法的可用性.

结论:

  • 先进的评分方法对于对AI驱动的蛋白质结构预测进行基准测试至关重要.
  • 提出的可扩展方法解决了大型,复杂的生物系统所带来的挑战.
  • 开放结构为结构基准和评估提供了一个全面的框架.