在联合化疗和免疫检查点抑制剂治疗期间,与免疫相关的不良事件相关的独特免疫细胞动态
Lei Zhang1, Xiaokai Fan2,3, Jun Ma4
1Department of Radiation Oncology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Nature communications
|December 22, 2025
概括
化学放射治疗和免疫治疗的结合会增加与免疫相关的不良事件 (irAEs). 这项研究揭示了irAE患者的T细胞升高和B细胞动态改变,特定的单细胞扩张和免疫细胞聚集在瘤中.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 化学辐射疗法与免疫疗法相结合可能导致与免疫相关的不良事件 (irAEs).
- 在这种情况下,驱动iRE的精确机制尚未完全理解.
- 了解这些机制对于管理治疗毒性至关重要.
研究的目的:
- 调查在接受联合治疗的局部晚期宫癌患者中,IRE背后的免疫机制.
- 为了确定特定的免疫细胞种群及其与irAE发展相关的变化.
- 开发对irAEs的预测模型.
主要方法:
- 对患者样本进行纵向单细胞多组体分析.
- 空间转录和免疫光学分析免疫细胞局部化.
- 开发用于irAEs的预测模型.
主要成果:
- 患有irAEs的患者中CD4+和CD8+终端分化功效记忆/功效T细胞的比例增加.
- 化学放射治疗改变了B细胞克隆性,并增加了irAE患者的IgA+/IgG+B细胞丰度和体质突变.
- 在瘤微环境中观察到特定单细胞子集群的扩张和与irAE相关的免疫细胞的聚合.
结论:
- 化学放射治疗和免疫治疗对各种免疫细胞有不同的影响,有助于irAE的发展.
- 特定的免疫细胞配置和它们在瘤微环境中的空间分布与irAEs有关.
- 开发的预测模型和数据门户可以帮助理解和管理irAEs.
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