焦虑和抑郁对血液恶性瘤结果的影响:系统性审查和元分析
Dorsa Salabat1,2, Samaneh Toutounchian1,2, Danyal Salabat3
1School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
BMC cancer
|December 22, 2025
概括
抑郁症显著影响血液恶性瘤患者的生存率. 早期的心理评估和干预对于改善这个脆弱群体的结果至关重要.
科学领域:
- 在瘤学瘤学.
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 血液性恶性瘤与高死亡率有关.
- 抑郁和焦虑在HM患者中很常见,可能会影响生存率.
- 这些心理状况在HM的预后意义需要澄清.
研究的目的:
- 系统地审查和元分析抑郁症或焦虑症与HMS患者的生存结果之间的关联.
- 量化抑郁和焦虑对整体存活率 (OS),无事件存活率 (EFS) 和癌症特定存活率 (CSS) 的预后影响.
- 探索观察到的关联中异质性的潜在来源.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 搜索了PubMed,SCOPUS和科学网的相关研究.
- 包括29项研究 (31个队列),包括419,054名HM患者.
- 进行了随机效应元分析,子组,灵敏度和元回归分析.
主要成果:
- 抑郁症与较低的整体存活率显著相关 (HR=1.17,95% CI:1.09-1.27).
- 焦虑与OS没有显著的关联,但与无事件生存率 (EFS) 较差有关.
- 发现并调整了出版偏差;样本大小部分解释了异质性.
结论:
- 抑郁症是与血液恶性瘤患者的总生存率降低相关的显著预后因素.
- 强调心理评估和及时干预HM护理的急需.
- 需要进一步的研究来阐明焦虑的作用,并制定有针对性的支持性护理策略.
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