在成熟的牙中使用自身非矿物化牙基质和牙真菌干细胞再生真菌-牙复合体:两个案例报告
Misako Nakashima1, Noriaki Yoshihashi2, Hiroyuki Tanaka3
1Future Health Medical Corporation, RD Dental Clinic, Kobe, Hyogo, 650-0047, Japan. nakashima-m@rdshikaclinic.com.
BMC oral health
|December 22, 2025
概括
使用自牙干细胞 (DPSC) 和非矿物化牙基质 (DDM) 的再生性内牙治疗成功地在成熟的牙中再生了牙桥梁. 这种方法为保存受损牙提供了一个有希望的替代方案.
科学领域:
- 牙周内科医院 牙周内科医院 牙周内科医院
- 再生医学是一种再生医学.
- 生物材料是一种生物材料.
背景情况:
- 在成熟牙中再生脉-牙复合体,而这些牙有缩性脉或顶病变,是具有挑战性的.
- 在这种情况下,对于一致的牙桥形成存在有限的临床证据.
- 本报告详细介绍了两种使用自主牙髓干细胞 (DPSC) 和非矿物化牙基质 (DDM) 的再生性内牙治疗 (RET) 的案例.
研究的目的:
- 在成熟的切口动物中评估RET与自身DPSC和DDM的疗效.
- 评估牙桥形成和功能恢复.
- 将结果与未经治疗的对照组或常规治疗方法进行比较.
主要方法:
- 两名成年患者的成熟切口受损,接受了RET.
- 分离了自身的DPSC并移植到根管系统中.
- 脱矿牙矩阵 (DDM) 被用作支架,并进行了道消毒.
- 案例1涉及一颗牙患有脉死和牙周围炎;案例2涉及一颗牙在根运河治疗后出现严重的冠状牙损失.
主要成果:
- 在案例1中,经过治疗的牙恢复了脉敏感性,形成了牙状桥 (>3毫米),并在52周后的MRI上显示了类似的脉状组织. 未经处理的对照牙失去了活力.
- 在案例2中,CBCT在48周后显示出一个明确的牙状桥延伸到脉腔.
- 定量CBCT证实,在两种情况下,再生组织的矿物质密度 (75-80%的原生牙) 逐渐增加,没有化或再吸收等不良事件.
结论:
- 自体DPSC与DDM相结合,支持牙状桥梁的形成和成熟的切口动物的功能恢复.
- 这种基于生物学的方法为传统的根管疗法提供了潜在的替代方案或辅助方案.
- 这些发现表明,RET可以有效地保护结构上受损的牙.
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