三级淋巴体结构与乳腺癌患者在新辅助化疗后的下尾残留节点负担有关
Zhihao Wei1,2, Konglan Lin1,2, Wen Deng3
1Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China.
European journal of medical research
|December 22, 2025
概括
乳腺癌中新辅助化疗 (NAC) 后的三级淋巴体结构 (TLS) 增加,与关节疾病减少相关. 更高的TLS密度与更好的结果有关,并与淋巴血管标记物有关.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 三级淋巴体结构 (TLSs) 与改善化疗反应和乳腺癌的结果有关.
- 新辅助化疗 (NAC) 在乳腺癌中增加TLS,可能调节瘤免疫微环境.
- 在NAC后的TLS和临床病理特征之间的关系仍然不清楚.
研究的目的:
- 为了研究TLS密度与乳腺癌患者的临床病理特征之间的关联,NAC.
- 在乳腺癌NAC治疗的背景下,探索TLS和淋巴血管之间的潜在关系.
主要方法:
- 对326名接受NAC治疗和304名未接受治疗的乳腺癌患者的临床病理学数据的回顾性分析.
- 血素 - - 素染色和免疫组织化学,以评估TLS和淋巴血管.
- 在位杂交RNA光 (RNA-FISH) 和基因表达分析以量化淋巴细胞标记物和TLS得分.
主要成果:
- 在NAC后的乳腺癌样本中观察到TLS密度增加 (p < 0.0001).
- 较高的TLS密度与NAC (p < 0.0167) 后残留关节疾病的较低阶段相关 (p < 0.0167).
- 淋巴血管密度和特定的淋巴标记与TLS密度和TLS基因得分有积极的关联.
结论:
- 在NAC治疗的乳腺癌中,TLS密度与尾残留节点负担的减少显著相关.
- 淋巴血管和TLS似乎在接受NAC的乳腺癌患者中存在潜在的关系.
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