一种针对Streptococcus pneumoniae的新型多表位mRNA疫苗候选人的in silico设计和表征

相关实验视频

Updated: Jul 17, 2026

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
08:53

Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092

Published on: October 2, 2017

31.3K

Jahangir Sabzevari1,2, Omid Ali Adeli3, Mona Shafaghi4,5

  • 1Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Scientific reports
|December 22, 2025
PubMed
概括

一个新的mRNA疫苗候选人,YAPO,显示了作为一种抗杆菌肺炎感染的血清型独立策略的希望. 计算分析预测它可以诱导强烈的免疫反应,提供一种潜在的新工具来对抗肺炎球菌疾病.

关键词:
免疫信息学是指免疫信息学.肺炎球菌内酸酶o (PepO) 的使用肺炎球菌mRNA疫苗的使用情况肺炎球菌的表面粘附a (PsaA)肺炎球菌的表面蛋白a (PspA)肺聚氨酸 (Ply) 是一种

更多相关视频

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes13:53

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

5.3K
Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

5.0K

相关概念视频

Gram-negative Bacterial Protein Secretion Systems01:17

Gram-negative Bacterial Protein Secretion Systems

Gram-negative bacteria utilize sophisticated protein secretion systems to transport proteins across their double-membrane envelope into the extracellular environment or host cells. Based on their mechanism of action, these systems are classified into one-step and two-step pathways.One-Step Secretion Systems (Types I, III, IV, and VI)One-step secretion systems bypass the periplasm entirely, forming a continuous channel that spans both the inner and outer membranes:Type I Secretion System (T1SS):...
Inhibitors of Bacterial Protein Synthesis01:25

Inhibitors of Bacterial Protein Synthesis

Aminoglycosides constitute a highly potent class of bactericidal antibiotics that exert their antimicrobial effects by targeting the bacterial ribosome, specifically disrupting protein synthesis. These polycationic molecules consist of amino-modified sugars linked via glycosidic bonds to an aminocyclitol core such as 2-deoxystreptamine or streptamine. Their strong positive charges facilitate tight binding to the negatively charged phosphate backbone of ribosomal RNA (rRNA), primarily at the 16S...