氧化和纳米泡在热和pH压力条件下的稳定性评估
Veranica Agustin1, Aditya Hernowo2,3
1Indonesian Molecular Innovation Foundation, Malang, 65151, Jawa Timur, Indonesia.
Scientific reports
|December 22, 2025
概括
纳米气泡 (NBs) 的稳定性因条件而异. 氧NBs在高温下降解,而NBs在中性pH下稳定,这对于治疗应用至关重要.
科学领域:
- 纳米医学和材料科学 纳米医学和材料科学
- 生物物理学和物理化学
背景情况:
- 纳米气泡 (NBs) 是具有治疗潜力的纳米级气体分散 (<200 nm).
- NB对环境因素敏感,影响其临床实用性.
- 了解NB稳定性是开发可靠药物输送系统的关键.
研究的目的:
- 为了评估氧化 (HHO) 和 (H2) 纳米泡在热和pH压力下的稳定性.
- 为了确定纳米泡配方弹性最佳条件.
- 为了告知基于纳米泡的疗法的设计.
主要方法:
- 产生HHO和H2纳米气泡.
- 暴露HHO纳米泡的热应力 (80°C,100°C,-17°C).
- 储存H2纳米泡在pH范围 (4-9) 内的7天.
- 使用纳米粒子追踪分析 (NTA) 进行尺寸和度的表征.
主要成果:
- 在100°C时,HHO纳米泡显示显著降解 (度降低,大小增加).
- 结对HHO纳米泡的稳定性产生了适度的影响.
- 在中性pH (6-7),H2纳米泡最稳定,在pH 4和pH 9降解.
- 极端的pH值和温度显著降低了纳米泡的稳定性.
结论:
- 中性pH (6-7) 是最佳的纳米泡稳定性.
- 高温 (100°C) 和冷显著损害了纳米泡的完整性.
- 这些发现指导了用于治疗气体输注和药物输送的稳定纳米泡配方的开发.
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