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直肠恶性黑色素瘤的临床和病理特征和相关性分析

Lei Xi¹, Jinxing Zhou, Yan Wu

¹Department of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

|December 23, 2025

概括

这项研究比较了中国和东亚患者的直肠恶性黑色素瘤 (AMM). 虽然许多特征是相似的,但瘤的位置和侵袭深度有很大的不同,影响治疗策略.

科学领域:

在瘤学瘤学.
胃肠病学胃肠病学
病理学病理学病理学

背景情况:

阳肠恶性黑色素瘤 (AMM) 是一种罕见且具有攻击性的癌症.
了解AMM呈现的种族和区域差异对于有效治疗至关重要.

研究的目的:

为了比较中国患者和东亚患者之间的AMM的临床和病理特征.
确定影响中国AMM患者淋巴转移的因素.

主要方法:

江苏省医院17名中国AMM患者 (2013-2023) 的回顾性分析.
与来自20个文献来源的544名东亚AMM患者 (2011-2023) 的比较.
使用皮尔森奇平方测试和费舍尔精确概率的统计分析.

主要成果:

诊断时的中位年龄为中国患者的69岁,东亚患者的61.4岁.
在性别,S-100蛋白,HMB45,Ki-67,瘤大小,淋巴转移和手术方法 (P > .05) 中观察到的相似之处.
在瘤位置,MART-1,入侵深度,临床阶段和辅助治疗 (P < .05) 中观察到的差异.
淋巴转移与中国AMM患者的瘤大小和入侵深度有显著的相关性 (P = .017和 .004).

结论:

在中国人和更广泛的东亚人口之间,AMM在临床和病理特征上表现出相似之处和明显的差异.
瘤大小和侵袭深度是中国AMM患者淋巴转移的关键指标.
根据AMM的区域差异,可能需要定制的诊断和治疗策略.

关键词:

东亚人口东亚人口江苏省医院江苏省医院直肠恶性黑色素瘤这是一项回顾性研究.

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