ABCB1 rs2032582变种可能与Scutellariae Radix引起的肝损伤有关:一个病例报告
Yiwen Tang1,2, Lihong Fu1,2, Xinrui Ren1,2
1Laboratory of Cellular Immunology, Shanghai Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai, China.
Medicine
|December 23, 2025
概括
一个罕见的特异性药物诱导性肝损伤 (IDILI) 病例与50岁女性的Scutellariae Radix有关. 基因分析揭示了ABCB1变异,这表明了对这种肝损伤的潜在倾向.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 药物基因组学 药物基因组学
- 传统中国医药 传统中国医药
背景情况:
- 非同步性药物诱导性肝损伤 (IDILI) 呈现出不可预测性和个体间的变异性.
- Scutellariae Radix是一种治疗肝脏疾病的草药,很少与肝脏损伤有关.
- 这份报告详细介绍了一例独特的肝损伤病例,该病例归因于Scutellariae Radix.
研究的目的:
- 报告一个罕见的Scutellariae Radix诱导的肝损伤病例.
- 调查可能导致观察到的肝损伤的遗传因素.
- 强调在肝功能障碍的差异诊断中考虑草药药物的重要性.
主要方法:
- 一名50岁的女性患者出现了发烧和肝脏功能障碍.
- 在排除其他原因后,确立了Scutellariae Radix诱导的肝损伤的诊断.
- 在ABCB1基因中进行了rs2032582变异的遗传分析.
主要成果:
- 患者的肝酶 (ALT,AST) 在停止草药和接受支持性护理后显著改善.
- 出院前肝功能正常化,在随访期间保持稳定.
- 在该患者身上发现了ABCB1的rs2032582变体.
结论:
- 这一案例突出了由Scutellariae Radix引起的IDILI的罕见实例.
- 存在ABCB1 rs2032582变异可能表明遗传倾向.
- 需要在更大的队列中进行进一步的研究,以确认遗传因素在Scutellariae Radix引起的肝损伤中的作用.
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