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循环微量营养素水平与双相情感障碍之间的因果关系:孟德尔的随机化研究
Ting You1, Xiuwen Yang1, Huaili Feng1
1Department of Health Laboratory Technology, School of Public Health, Chongqing Medical University, Chongqing, People's Republic of China.
Medicine
|December 23, 2025
概括
维生素B12和胡卜素的较高水平与双相情感障碍 (BD) 的风险增加有关. 这项研究使用了门德尔的随机化来探索微量营养素对BD的影响,确定潜在的营养因素. 需要进一步的研究.
科学领域:
- 精神病学和遗传学 精神病学和遗传学
- 营养科学 营养科学
背景情况:
- 双极性障碍 (BD) 是一种复杂的心理健康状况,具有重要的遗传成分.
- 循环微量营养素在BD病因学中的作用尚不清楚.
- 了解这些因素可以为新的干预策略提供信息.
研究的目的:
- 调查15种循环微量营养素对双相情感障碍 (BD) 风险的潜在因果影响.
- 使用两个样本的门德尔随机化 (MR) 来评估微量营养素和BD之间的遗传关联.
- 为了确定可能影响BD易感性的特定微量营养素.
主要方法:
- 采用双样本门德尔随机化 (MR) 和多个MR分析.
- 利用了微量营养素的全基因组关联研究 (GWAS) 数据和来自FinnGen联盟的BD病例控制数据.
- 应用逆方差加权 (IVW) 作为主要分析方法,并对异质性和平性进行灵敏度分析 (MR-Egger,加权中位数,MR-PRESSO).
主要成果:
- 基因预测的维生素B12水平升高与BD风险增加有显著关联 (OR=1.81,P=0.005).
- 更高的基因预测的胡卜素水平也与增加的BD风险相关 (OR=1.49,P=0.017).
- 在BD和其他评估的微量营养素之间没有发现显著的因果关系;敏感性分析证实了强度.
结论:
- 表明更高的维生素B12和胡卜素循环水平可能与双极性障碍的风险增加有关.
- 突出了BD预防或管理的潜在营养目标.
- 呼吁进行进一步的研究,以阐明这些协会背后的机制.
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