鉴定和分析患有急性缺血性中风,接受血栓治疗的患者预后不佳的危险因素
Cuihong Ma1,2, Lixia Gao3, Zengkun Hong2
1Department of Neurology, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Tianjin Medical University, Dagang, Binhai New Area, Tianjin, China.
Medicine
|December 23, 2025
概括
预测急性缺血性中风 (AIS) 患者接受血栓抑制剂治疗的不良预后至关重要. 结合糖尿病,NIHSS,WBC,中性粒细胞计数和D-二次体的新诺米图显示了早期风险识别的前景.
科学领域:
- 神经学 神经学
- 生物医学科学 生物医学科学
- 临床医学 临床医学
背景情况:
- 在急性缺血性中风 (AIS) 后对高风险患者的早期鉴定对于有效的临床管理至关重要.
- 需要预测工具来指导AIS患者的治疗决策和资源分配.
研究的目的:
- 开发和内部验证用于预测AIS患者治疗复合组织等离子体激活剂的90天结果的预后性名录.
- 确定该患者队列中预后不佳的独立临床和实验室预测因素.
主要方法:
- 对286名AIS患者的回顾性分析,这些患者接受了血栓溶解治疗.
- 多变量逻辑回归用于识别预后不良的预测因素 (修改的兰金尺度>2).
- 使用接收机运行特征分析,Bootstrap重抽样和决策曲线分析开发和验证名ogram.
主要成果:
- 确定了5个预后不佳的独立预测因素:糖尿病,入院国家卫生研究院中风量表 (NIHSS) 评分,白细胞 (WBC) 计数,中性粒细胞计数和D-二次体水平.
- 开发的名图表显示出优异的分辨率 (AUC = 0.896) 和良好的校准.
- 内部验证显示一致性指数为0.728,表明良好的预测性能.
结论:
- 糖尿病,入院NIHSS得分,白细胞计数,中性粒细胞计数和D-二次体水平是接受血栓治疗的AIS患者预后不佳的重要预测因素.
- 开发的诺米图为早期风险分层和临床决策提供了有价值的工具.
- 建议进一步进行前性,多中心的验证,以证实名图在常规临床实践中的实用性.
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