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Updated: May 7, 2026

Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes

Measuring Bacterial Load and Immune Responses in Mice Infected with Listeria monocytogenes

Published on: August 9, 2011

怀孕期间艾滋病患者的Listeria monocytogenes bacteremia:一个病例报告

Xia Zhang¹, Xiang Hu, Ling Zeng

¹Department of Clinical Laboratory, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, China.

|December 23, 2025

概括

本案例研究突出了一个罕见的Listeria monocytogenes感染在HIV阳性孕妇的例子. 及时诊断和治疗为母亲和婴儿带来了有利的结果,强调了在共同感染中需要保持警.

科学领域:

医学微生物学医学微生物学
传染性疾病传染性疾病
免疫学免疫学免疫学

背景情况:

患有获得性免疫缺陷综合征 (艾滋病) 的怀孕增加了对机会性细胞内病原体的敏感性.
李斯特菌单细胞菌 (L. monocytogenes) 是一种罕见但致命的病原体,在艾滋病毒阳性孕妇中,经常导致严重的孕产妇和胎儿并发症.
怀孕期间与艾滋病毒和L. monocytogenes的同时感染,由于双重免疫抑制,具有重大临床挑战.

研究的目的:

报告一个罕见的Listeria monocytogenes bacteremia病例,该病例发生在患有人类免疫缺陷病毒 (HIV) 的孕妇身上.
强调早期检测和适当管理免疫功能低下的孕妇机会性感染的重要性.
在高风险的共感染场景中突出显示成功的治疗结果.

主要方法:

一个病例报告,一名36+2周怀孕的艾滋病毒阳性女性呈现持续发烧和炎症标志物升高的情况.
诊断工作包括血液培养,可以识别L. monocytogenes.
由于对β-乳酸过敏,治疗包括linezolid, imipenem和cilastatin的联合治疗方案.

主要成果:

在艾滋病毒阳性孕妇患者中确诊了Listeria monocytogenes bacteremia.
患者接受了量身定制的抗生素治疗方案,包括linezolid, imipenem 和 cilastatin.
在成功治疗后,母亲和新生儿都在健康状态下出院.

结论:

怀孕期间HIV和L. monocytogenes的同时感染非常罕见,但与高死亡率有关.
在艾滋病毒阳性孕妇中早期识别无法解释的发烧对于及时诊断利性感染如李斯特菌至关重要.
在这些罕见的情况下,有效和精确的干预对于优化母亲和婴儿的结果至关重要.

关键词:

艾滋病艾滋病艾滋病是什么?细菌病的细菌病是什么意思怀孕怀孕怀孕怀孕怀孕

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